| abstract |
The present invention is directed to new NOS variants or mutants comprising structural alterations at the site of Akt dependent phosphorylation. Altered NOS proteins or peptides, especially human eNOS proteins or peptides, Akt proteins or polypeptides and their encoding nucleic acid molecules include diseases with restenosis, hypertension, atherosclerosis, heart failure, diabetes, and angiogenesis after angioplasty It is useful as a gene therapy to treat diseases. NOS proteins and peptides are also useful in methods for screening for agents that modulate NOS activity.n n n n NOS mutation, eNOS, gene therapy |