http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100731271-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4465 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 |
| filingDate | 2000-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2007-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2007-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-100731271-B1 |
| titleOfInvention | Respiratory synthium virus replication inhibitor |
| abstract | The present invention relates to compounds of formula (I), their prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemical isomers as respiratory syntium virus replication inhibitors:n n n n n n n n Wheren n n -a 1 = a 2 -a 3 = a 4 -is represented by the formula -CH = CH-CH = CH-, = CH-CH = CH-, -CH = N-CH = CH-, -CH = CH-N = Is a radical of CH—, —CH═CH—CH═N—, wherein each hydrogen atom may be optionally substituted,n n n Q is represented by formulas (b-1), (b-2), (b-3), (b-4), (b-5), (b-6), (b-7), (b-8) Represents a radical of; From here,n n n Alk is C 1-6 alkanediyl;n n n Y 1 is a divalent radical of the formula -NR 2 -or -CH (NR 2 R 4 )-;n n n X 1 is NR 4 , S, S (= O), S (= O) 2 , O, CH 2 , C (= O), C (= CH 2 ), CH (OH), CH (CH 3 ), CH (OCH 3 ), CH (SCH 3 ), CH (NR 5a R 5b ), CH 2 -NR 4 or NR 4 -CH 2 ;n n n X 2 is a direct bond, CH 2 , C (═O), NR 4 , C 1-4 alkyl-NR 4 , NR 4 -C 1-4 alkyl;n n n t is 2, 3, 4 or 5; u is 1, 2, 3, 4 or 5; v is 2 or 3;n n n From here,n n n Alk and each hydrogen atom in the radicals (b-3), (b-4), (b-5), (b-6), (b-7) and (b-8) are each optionally substituted by R 3 . Can be; Provided that when R 3 is hydroxy or C 1-6 alkyloxy R 3 is not capable of replacing a hydrogen atom at the α position relative to a nitrogen atom;n n n G is substituted C 1-10 alkanediyl; Wherein the substituents are attached via an oxygen atom;n n n R 1 is optionally substituted monocyclic heterocycle or aryl;n n n R 2 is hydrogen, formyl, C 1-6 alkylcarbonyl, Hetcarbonyl, pyrrolidinyl, piperidinyl, homopiperidinyl, N (R 6 ) 2 and C 3-7 substituted with another substituent Cycloalkyl, or C 1-10 alkyl;n n n R 3 is hydrogen, hydroxy, C 1-6 alkyl, C 1-6 alkyloxy, arylC 1-6 alkyl or arylC 1-6 alkyloxy;n n n R 4 is hydrogen, C 1-6 alkyl, arylC 1-6 alkyl;n n n R 5a , R 5b , R 5c and R 5d are each independently hydrogen or C 1-6 alkyl;n n n R 5a and R 5b , or R 5c and R 5d together form a divalent radical of the formula — (CH 2 ) s — where s is 4 or 5;n n n R 6 is hydrogen, C 1-4 alkyl, formyl, hydroxyC 1-6 alkyl, C 1-6 alkylcarbonyl or C 1-6 alkyloxycarbonyl;n n n Aryl is optionally substituted phenyl;n n n Het is pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl.n n n The invention also relates to their preparation, compositions containing them, and their use as medicaments. |
| priorityDate | 1999-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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