| abstract |
The present invention relates to a polynucleotide comprising a nucleotide sequence encoding the aveC gene product, wherein the polynucleotide molecule comprises a ratio or amount of the series 2: 1 avermectin produced in the fermentation culture of Streptomyces avermitilis. Can be used to change. The invention also relates to a variant strain of Streptomyces avermitilis, wherein the vector, host cell, and aveC gene have been mutated to alter the ratio or amount of inactivated or produced class 2: 1 avermectins. |