| abstract |
Novel 4-aminopyrimidin-5-one derivatives of Formula (I) are described;n n n [Formula I]n n n n n n n n [Wherein, R 1 and R 2 are as defined in the specification]. These compounds inhibit cyclin-dependent kinases, in particular cyclin-dependent kinase 4 (Cdk4). These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful for the treatment or control of cancer, in particular solid tumors. The invention also relates to pharmaceutical compositions containing such compounds, their use in the treatment or control of cancer, methods of their preparation and intermediates useful for their preparation. |