| abstract |
The present invention provides a triazaspiro [5.5] undecane derivative represented by the general formula (I), quaternary ammonium salts thereof, N-oxides thereof, non-toxic salts thereof, and a pharmaceutical agent containing the same as an active ingredient.n n n n Formula (I)n n n n n n n n n [Wherein R 1 is represented by the formula (II), Groups of formula (III), Represents a group of; R 2 represents alkyl, alkynyl and the like; R 3 and R 4 each represent H, (substituted) alkyl, or the like, or R 3 and R 4 together represent formula (IV), Can represent groups of; R 5 represents H, alkyl.]n n n Since the compound represented by the formula (I) controls the action of the chemokine / chemokine receptor, it is possible to prevent various inflammatory diseases, asthma, atopic dermatitis, dartazine, allergic diseases, nephritis, nephritis, hepatitis, arthritis, chronic arthritis And / or for treatment. |