| abstract |
Disclosed are compounds such as Formulas (Ia) and (Ib) that bind to VLA-4. Some of these compounds also inhibit leukocyte adhesion, in particular leukocyte adhesion mediated by VLA-4. Such compounds are useful for the treatment of inflammatory diseases such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, cancer metastasis and myocardial ischemia in mammals, for example human patients. Do. The compound may also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis. |