http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100681911-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_717c792fca7cc9c290c9db33e8fe078b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0071 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-409 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-22 |
| filingDate | 2006-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2007-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a5d4b11b38b289f3e42eb31b5a4d3f25 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5585c148392405598766d55431dff99c |
| publicationDate | 2007-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-100681911-B1 |
| titleOfInvention | 5,10,15,20-tetrakis- (2-fluoro-pyridin-3-yl) -porphyrin, 5,10,15,20-tetrakis- (3,5-difluoro-pyridine-4 1)-Porphyrins, N-alkyl salts thereof, and preparation methods thereof |
| abstract | 5,10,15,20-tetrakis- (2-fluoro-pyridin- 3-yl) -porphyrin and its derivatives 5,10,15,20-tetrakis- (1-alkyl-2 fluoro- Pyridinium-3-yl) -porphyrin salt, 5,10,15,20-tetrakis- (3,5-difluoro-pyridin-4-yl) -porphyrin and its derivatives 5,10,15,20 Tetrakis- (1-alkyl-3,5-difluoro-pyridinium-4-yl) -porphyrin salts, and methods for their preparation are disclosed. The method for preparing 5,10,15,20-tetrakis (2-fluorofluoropyridin-3-yl) -porphyrin is quantitatively determined by pyrrole with 2-fluoropyridine-3-carbaldehyde as a starting material. By reaction to form 5,10,15,20-tetrakis- (2-fluoro-pyridin-3-yl) -porphyrin 5,10,15,20-tetrakis- (2-fluoro 5,10,15,20-tetrakis- (1 -alkyl-2 -fluoro-pyridinium-3 -yl) -porphyrin salts, which are derivatives of -pyridin-3-yl) -porphyrin; It is prepared by forming an N-alkyl salt in a pyridine constituting 20-tetrakis (2-fluorofluoropyridin-3-yl) -porphyrin, and 5,10,15,20-tetrakis (3). In the preparation of, 5-difluoro-pyridin-4-yl) -porphyrin, pyrrole is used as starting material with 3,5-difluoro-pyridine-4-carbaldehyde. And quantitative reaction to form 5,10,15,20-tetrakis- (3,5-difluoro-pyridin-4-yl) -porphyrin. (3,5-Difluoro-pyridin-4-yl)-5,10,15,20-tetrakis- (1-alkyl-3,5-difluoro-pyridinium-4-yl) which is a derivative of porphyrin The porphyrin salt is prepared by forming an N-alkyl salt on the pyridine constituting 5,10,15,20-tetrakis (3,5-difluoro-pyridin-4-yl) -porphyrin. The above-mentioned 5,10,15,20-tetrakis- (2-fluoro-pyridin-3-yl) -porphyrin and 5,10,15,20-tetrakis- (3,5-difluoro- Pyridin-4-yl) -porphyrins have antimicrobial, antimicrobial and anticancer properties and also act as photosensitizers, and according to the invention, 5,10,15,20-tetrakis- (1-alkyl-2-fluoro) Pyridinium-3-yl) -porphyrin salts and 5,10,15,20-tetrakis- (1-alkyl-3,5-difluoro-pyridinium-4-yl) -porphyrin salts have high solubility in aqueous solutions. At the same time, it has antimicrobial, antimicrobial and anticancer effects, and has a function of a photosensitizer, which can be used in the development of bioactive substances such as antimicrobials, antibiotics and anticancer agents, and can be effectively used for photoactive therapy as a photosensitive agent. In particular, as an anticancer agent has a selective activity on cancer cells can be effectively used in cancer treatment. In addition, it can be effectively used as a material having a photosensitizer function when developing electronic materials. |
| priorityDate | 2006-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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