| abstract |
The present invention provides compounds of formula (I) and methods for their preparation which are useful for the synthesis of biologically active compounds:n n n Formula In n n n n n n n Wheren n n R 1 and R 2 are independently selected from H, C 1 -C 12 alkyl or C 1 -C 6 perfluorinated alkyl;n n n X is a leaving group;n n n A is O or S;n n n m is an integer from 1 to 3, preferably 2;n n n R 3 , R 4 , R 5 and R 6 are H, halogen, —NO 2 , alkyl, alkoxy, C 1 -C 6 perfluorinated alkyl, OH or C 1 -C 4 ester or alkyl ethers thereof, —CN, -OR 1 , -O-Ar, -SR 1 , -S-Ar, -SO-R 1 , -SO-Ar, -SO 2 -R 1 , -SO 2 -Ar, -CO-R 1 , -CO Independently from -Ar, -CO 2 -R 1 or -CO 2 -Ar;n n n Y is a) residues Wherein R 7 and R 8 are independently selected from H, C 1 -C 6 alkyl or phenyl), orn n n b) substituted or containing no more than two hetero atoms selected from the group consisting of -O-, -NH-, -N (C 1 -C 4 alkyl)-, -N = and -S (O) n- Unsubstituted 5-, 6- or 7-membered saturated, unsaturated or partially unsaturated heterocycle or acyclic heterocycle.n n n Aryloxy-alkyl-dialkylamines, matrix metalloproteinases, |