http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100635884-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-072 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2015-8545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0312 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
| filingDate | 2004-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2006-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2006-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-100635884-B1 |
| titleOfInvention | Bitransgenic dementia mice expressing the PS2 mutant gene and the TA gene |
| abstract | The present invention relates to a bitransgenic dementia mouse expressing a hPS2 mutant gene and a tetracycline transactivator (TAK) gene, and more specifically, a promoter of a recombinant gene and a pTet gene in which a promoter of the pTet gene is linked to a TAK gene. Microinjection of the recombinant gene linking the promoter to the hPS2m gene into the fertilized egg of the mouse, respectively, and to produce the transformed mouse produced by transplanting the fertilized egg into the oviduct of the surrogate mother mouse, the transgenic mouse It relates to a dual transgenic dementia mouse produced by mating.n n n Transgenic dementia mice according to the present invention are capable of controlling expression of the PS2 gene and exhibit behavioral abnormalities similar to those of human dementia patients, amyloid β-42 accumulation, Tau protein activation, and catenin activation. In addition, it can be very useful for the development of treatment for dementia disease or early diagnosis of dementia disease.n n n n Dementia * Alzheimer's Disease * Tetracycline-induced Dementia Mice * PS2 * Amyloid β-42 * Tau Protein * Catenin |
| priorityDate | 2004-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 113.