| abstract |
The present invention is directed to the treatment of diseases or medical conditions mediated by amide derivatives of formula (1) or pharmaceutically acceptable salts thereof or biodegradable esters thereof, methods for their preparation, pharmaceutical compositions containing them and cytokines It is about how to use:n n n Formula 1n n n n n n n n In the above formula,n n n R 1 and R 2 include hydroxy, C 1-6 alkoxy, mercapto, C 1-6 alkylthio, amino and heterocyclyl,n n n m and p are independently 0 to 3,n n n R 3 is halo, cyano or C 1-6 alkoxy,n n n q is 0 to 4,n n n R 4 is aryl or cycloalkyl, wherein R 4 is optionally substituted with up to 3 substituents having any value defined by each R 1 group. |