| abstract |
The present invention relates to a process for the preparation of Form I of cabergoline, which comprises the preparation of Form V using heptane as a precipitation solvent and the exclusive conversion of cabergoline to Form I. This crystallization process from the toluene-heptane solvent system for Form V involves the "back addition" of the toluene-cabergoline concentrate to cold heptane.n n n n Cabergoline Form I, Solvate Form V, Toluene-heptane, Reverse Add |