| abstract |
The present invention relates to compounds of formula (I) and pharmaceutically acceptable acid addition salts thereof:n n n Formula In n n n n n n n Wheren n n R is hydrogen; -(CH 2 ) n -phenyl optionally substituted with halogen, lower alkyl, lower alkoxy, trifluoromethyl or -N (R ')-C (O) -lower alkyl; -(CH 2 ) n -pyridinyl optionally substituted with lower alkyl; -(CH 2 ) n -C 3-6 -cycloalkyl optionally substituted with hydroxy; -(CH 2 ) n -N (R ')-C 3-6 -cycloalkyl; -(CH 2 ) n -benzo [1,3] -dioxolyl; -(CR ' 2 ) n -thiophenyl optionally substituted with lower alkyl; -(CR ' 2 ) n -thiazolyl optionally substituted with lower alkyl; -(CH 2 ) n -C (O) -thiophenyl optionally substituted with halogen; -(CH 2 ) n -furanyl optionally substituted with lower alkyl; -(CH 2 ) n -C (O)-(CH 2 ) n -thiophenyl; -(CHR ') n -benzofuran-2-yl; -(CH 2 ) n -benzo [b] thiophenyl optionally substituted with lower alkyl; -(CH 2 ) n -N (R ')-C (O) -phenyl optionally substituted with halogen or lower alkoxy; -(CH 2 ) n -C (O) -phenyl optionally substituted with lower alkoxy; -(CH 2 ) n -C (O) -2,3-dihydro-benzo [1,4] dioxin-6-yl; -(CH 2 ) n -N (R ')-C (O) -pyridinyl; -(CH 2 ) n -tetrahydrofuranyl; -CH-bi-phenyl; -CH (phenyl) -pyridinyl; -(CH 2 ) n -1-oxo-1,3-dihydro-isoindol-2-yl; -(CH 2 ) n -1,3-dioxo-1,3-dihydro-isoindol-2-yl; -(CH 2 ) n -CH (phenyl) -tetrahydropyranyl,-(CH 2 ) n -1-oxo-1,2,3,4-tetrahydro-isoquinolin-3-yl; Or-(CH 2 ) n -S- [1,3,4] thiazol-2-yl optionally substituted with amino;n n n R 'and R' 2 are, independently from each other, hydrogen or lower alkyl;n n n n is 0, 1, 2, 3 or 4.n n n The compounds of formula I have good affinity for the A 2A receptor and are therefore useful for the treatment of diseases associated with this receptor. |