| abstract |
Various biological reactions involving immunizing human antibody-producing transgenic mice produced by genetic engineering techniques using AILIM molecules as antigens, which can bind to AILIM and are involved in the transmission of AILIM-mediated substimulatory signals (secondary signals) Various human monoclonal antibodies have been prepared that can modulate (eg, cell proliferation, cytokine production, immune cytolysis, cell death, induction of ADCC, etc.). Moreover, the human monoclonal antibodies have been shown to be effective in treating and preventing various diseases associated with AILIM-mediated substimulus signal transduction, and to inhibit the onset and / or progression of such diseases. |