| abstract |
The present invention relates to a hydroxamic acid derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the same, and a pharmaceutical use thereof:n n n n n n n n In the formula, each symbol is as described in the specification.n n n The hydroxamic acid derivatives or pharmacologically acceptable salts thereof of the present invention have a TNFα production inhibitory activity, such as sepsis, MOF, chronic arthritis rheumatoid, Crohn's disease, cachexia, severe joint atresia, systemic disc lupus erythematosus, It is useful for the prevention and treatment of asthma, type I diabetes, psoriasis, other autoimmune diseases, and inflammatory diseases. |