| abstract |
The compound of general formula (I) is an antibiotic.n n n n n n n n In this expressionn n n R 1 represents hydrogen or C 1 -C 6 alkyl, or C 1 -C 6 alkyl substituted by one or more halogen atoms;n n n R 2 represents R 10- (X n )-(ALK) m- , wheren n n R 10 represents hydrogen or a C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, cycloalkyl, aryl or heterocyclyl group, either of which is unsubstituted (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, hydroxy, mercapto, (C 1 -C 6 ) alkylthio, amino, halo (including fluoro, chloro, bromo and iodo), trifluoromethyl, Cyano, nitro, -COOH, -CONH 2 , -COOR 4 , -NHCOR A , -CONHR A , -NHR A , -NR A R B or CONR A R B , where R A and R B are each (C 1 -C 6 ) alkyl group)n n n ALK represents a straight or branched divalent C 1 -C 6 alkylene, C 2 -C 6 alkenylene or C 2 -C 6 alkenylene group, and one or more non-adjacent, -NH-, -O- or- Blocked by S-coupler,n n n X represents -NH-, -O- or -S-,n n n m and n are 0 or 1, respectively.n n n A represents a group defined in the specification. |