| abstract |
The present invention relates to α-amino acid phenyl ester derivatives of the general formula (1) or pharmaceutically acceptable salts thereof. The present invention also relates to pharmaceutical compositions comprising such derivatives and the use of α-amino acid phenyl ester derivatives as hypnotics to induce and maintain general anesthetic conditions.n n n Formula 1n n n n n n n n [Wherein, R 1 is (C 1-3 ) alkyloxy;n n n R 2 is (C 1-3 ) alkyl, (C 1-3 ) alkyloxy or (C 2-3 ) alkenyl;n n n R 3 is hydrogen, (C 1-3 ) alkyl, (C 1-3 ) alkyloxy or (C 2-3 ) alkenyl;n n n R 4 is (C 1-6 ) alkyl;n n n R 5 and R 6 are independently (C 1-6 ) alkyl, (C 2-6 ) alkenyl, (C 2-6 ) alkynyl or aralkyl, each of which is (C 1-3 ) alkyloxy, ( C 1 to 3 ) alkyloxycarbonyl, cyano or NR 7 R 8 may be substituted;n n n R 7 and R 8 are independently (C 1-6 ) alkyl] |