| abstract |
Small particle liposome aerosol compounds and methods of treatment of the present invention include a fat-soluble or water-soluble anticancer agent incorporated into liposomes. Liposomes are administered to an individual's airways in the form of an aqueous dispersion from a jet nebulizer. Various anticancer agents can be used, including 20-S-camptothecin, 9-nitro-camptothecin, 9-amino-camptothecin, 10,11-methylenedioxy-camptothecin and taxol or derivatives thereof. By inhalation of the drug, the anticancer agent is absorbed more quickly and more efficiently than by intramuscular or oral administration.n n n n Small particle liposome aerosol, camptothecin, dilauroylphosphatidylcholine, aqueous dispersion of anticancer agent, nebulizer, inhalation |