| abstract |
The present invention includes introducing a near-infrared fluorescence contrast agent comprising a compound having three or more sulfonic acid groups in a molecule and a near-infrared fluorescence contrast agent of the present invention into a living body and exposing the body to an excitation light source to detect near-infrared fluorescence from the contrast agent It provides a fluorescence imaging method. The near-infrared fluorescence contrast agent of the present invention is excited by an excitation light source and emits near-infrared fluorescence. Such infrared fluorescence is excellent in permeability through the living tissue. Thus, detection of lesions in deep regions of the living body becomes possible. In addition, the contrast agent of the present invention is excellent in water solubility, low toxicity can be used safely.n n n Near-infrared fluorescence contrast agent, fluorescence imaging method, water solubility, acute toxicity, excitation light source. |