| abstract |
The present invention relates to compounds of formula (IA) or (IB) and their pharmaceutically acceptable acid addition salts. Compounds of formula (IA) or (IB) have been found to be adenosine receptor ligands. In particular, the compounds of the present invention have good affinity for the A 2A receptor and are therefore useful for treating diseases associated with such receptors:n n n Formula IAn n n n n n n n Formula IBn n n n n n n n Wheren n n R 1 is phenyl, piperidin-1-yl or morpholinyl;n n n A is -O-,n n n R is-(CR 2 ) n -N (R ")-C (O) -lower alkyl,-(CH 2 ) n -O-lower alkyl,-(CH 2 ) n -O- (CH 2 ) n- O- lower alkyl, lower alkyl, - (CH 2) n - morpholinyl, - (CH 2) n - phenyl, - (CH 2) n -N (R ") 2, - (CH 2) n - pyrido Diyl, â (CH 2 ) n âCF 3 , â (CH 2 ) n -2-oxo-pyrrolidinyl or C 4-6 -cycloalkyl, R â³ are independently of each other hydrogen or lower alkyl, n is 1 or 2; orn n n A is -N (R ')-,n n n R is lower alkyl, C 4-6 -cycloalkyl,-(CH 2 ) n -O-lower alkyl,-(CH 2 ) n -pyridinyl,-(CH 2 ) n -piperidinyl,-(CH 2 ) n - phenyl, - (CH 2) n -N (R ") - C (O) - lower alkyl, - (CH 2) n - morpholinyl or - (CH 2) n -N ( R") 2 R 'and R "are, independently from each other, hydrogen or lower alkyl, n is 1 or 2; orn n n A is -CH 2- ,n n n R is -N (R ")-(CH 2 ) m -O-lower alkyl, -N (R") 2 , -S-lower alkyl, or acetidinyl, optionally substituted with hydroxy or lower alkoxy, p Is rolledinyl or piperidinyl, or morpholinyl, -N (R ")-(CH 2 ) m -C 4-6 -cycloalkyl, -N (R")-(CH 2 ) m -C (O) O-lower alkyl, -N (R ")-(CH 2 ) m -C (O) OH, 2-oxo-pyrrolidinyl, -N (R")-C (O) O-lower alkyl, -O (CH 2 ) m- O-lower alkyl or alkoxy, R "is independently of each other hydrogen or lower alkyl, m is 1, 2 or 3; orn n n A is -S-,n n n R is lower alkyl; orn n n AR is piperazinyl substituted with lower alkyl, -C (O) -lower alkyl or oxo group together, piperidinyl substituted with lower alkoxy or hydroxy, morpholinyl substituted with lower alkyl, hydroxy or -C 4-6 -cycloalkyl, -azetidin-1-yl, optionally substituted with lower alkoxy, thiomorpholine-1,1-dioxo, -tetrahydropyran or 2-oxa-5-aza-bi Cyclo [2.2.1] hept-5-yl. |