http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100573861-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-32 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-32 |
| filingDate | 2003-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2006-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2006-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-100573861-B1 |
| titleOfInvention | Method for preparing 2-amino-9,8-dichloro-9- (2-hydroxyethyl) purine as 2-amino-9- (2-halogenoethyl) purine and its intermediates |
| abstract | The present invention provides a structural formula (I) useful as an intermediate in the preparation of a purine derivative drug having antiviral activity using 2-amino-6,8-dichloro-9- (2-hydroxyethyl) purine of the novel structural formula (III). As a method for producing 2-amino-9- (2-halogenoethyl) purine ofn n n The preparation process according to the invention is carried out by reacting a compound of formula (V) with a compound of formula (VI) or formula (VII) in a polar organic solvent in the presence of a base to obtain a novel compound according to the invention of formula (III) And reacting it in a polar organic solvent in the presence of a desalting agent to produce a compound of formula (II), followed by reacting a halogenating agent in a polar or nonpolar organic solvent,n n n (Formulas I, II, III, V, VI, VII)n n n n n n n n Wherein X is a halogen atom.n n n According to the preparation method of the present invention, 2-amino-9- (2-halogenoethyl) purine can be obtained at a high yield under simpler and milder reaction conditions, and as a novel intermediate, 2-amino-6,8- Besides obtaining dichloro-9- (2-hydroxyethyl) purine, 2-amino-6,8-dichloro-9- (2-hydroxyethyl) purine can be efficiently produced with high selectivity.n n n 2-amino-9- (2-halogenoethyl) purine, 2-amino-6,8-dichloro-9- (2-hydroxyethyl) purine |
| priorityDate | 2003-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 118.