| abstract |
The present invention is formula (1)n n n n n n n n Wherein R 1 represents a lower alkoxy group, a lower alkylthio group or a halogen atom; R 2 represents H, a lower alkoxy group, a lower alkylthio group or a halogen atom; R 3 represents OH, CN, a halogen atom, a lower atom A lower alkyl group or a lower alkenyl group which may be substituted with a cycloalkyl group, a (substituted) aromatic group and a (substituted) carbamoyl group; R 4 represents a COOH, a lower alkoxycarbonyl group, a (substituted) carbamoyl group, a (substituted) thiocarbamo A diary, a (substituted) amino group or a (substituted) ureido group; a dashed line indicates that the bond between the carbon positions at the 4 and 5 positions is a single bond or a double bond)n n n It relates to a pyridazine derivative or a salt thereof and a medicament using the same as an active ingredient. This compound has excellent interleukin-1β production inhibitory action and is useful as a prophylactic and therapeutic agent for immune system diseases, inflammatory diseases, ischemic diseases and the like. |