| abstract |
Improved ophthalmic compositions comprising prostaglandin actives are particularly useful for lowering intraocular pressure in connection with glaucoma. IOP reduction efficacy by using a composition described herein comprising a selected nonionic surfactant, preservative and nonionic osmotic modulator, in combination with a prostaglandin active agent (e.g., isopropyl unoprostone, a metabolite of F family prostaglandin), Aspects of preservative efficacy and lowering of additive concentrations can be improved.n n n Intraocular pressure, prostaglandins, nonionic surfactants, preservatives, nonionic osmotic agents, antiseptic agents |