abstract |
The present invention relates to prodrug compounds of dipeptidyl peptidase IV (DP IV) inhibitors. The prodrug compound comprises formulas A-B-C, wherein A is an amino acid, B is a chemical bond or amino acid between A and C, and C is a stable inhibitor of DP IV. The prodrug compounds are used in the treatment of altered glucose tolerance, diabetes, hyperlipidemia, metabolic acidosis, diabetes mellitus, diabetic neuropathy and nephropathy, and secondary diseases caused by diabetes mellitus in mammals. |