http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100517262-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-66 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| filingDate | 1996-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2005-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2005-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-100517262-B1 |
| titleOfInvention | Non-Toxic Mutants of Pathogenic Gram-Negative Bacteria |
| abstract | The present invention provides a method for identifying, isolating and producing htrB variants of pathogenic Gram-negative bacteria. The method mutated the htrB gene of a pathogenic Gram-negative bacterium to lack a functional htrB protein, thus lacking at least one secondary acyl chain contained in the wild-type pathogenic Gram-negative bacterium and substantially reduced compared to the wild-type strain. You get variants that show toxicity. In addition, the present invention relates to a method in which an htrB variant, an endotoxin isolated therefrom or an endotoxin isolated therefrom is conjugated with a carrier protein to immunize an individual against infection by a pathogenic Gram-negative bacterium by administering a prophylactically effective amount of a vaccine formulation. A method of using a vaccine formulation containing the same is provided. |
| priorityDate | 1995-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 169.