| abstract |
The present invention relates to compounds of formula (I) and pharmaceutically acceptable acid addition salts thereof. The compound can be used for the treatment of neurodegenerative diseases.n n n Formula In n n n n n n n Wheren n n Ar 1 is pyridyl or phenyl substituted with hydroxy, lower alkyl, halogen, amino, nitro, benzyloxy or lower alkoxy-lower alkoxy, or formula (a) Wherein Z 1 is a 5 membered heterocyclic ring containing 1 or 2 heteroatoms selected from N or O; R 1 is hydrogen, hydroxy or oxo group;n n n Ar 2 is pyridyl or phenyl optionally substituted with hydroxy, lower alkyl, halogen, amino, nitro, benzyloxy or lower alkoxy-lower alkoxy, or formula (b) Wherein Z 2 is a 5 or 6 membered ring optionally containing 1 or 2 heteroatoms selected from N or O;n n n Q is -S-, -S (O)-or -S (0) 2- ;n n n X is a bond, -CH (OH)-or-(CH 2 ) n- ;n n n A is a bond or-(CHR) m- , wherein R is independently of each other hydrogen, halogen or hydroxy when m is 2 or 3;n n n Y is-(CR 2 ) m- , -0-, -C = C-, -C≡C-, piperidin-1-yl, pyrrolidin-1-yl or C 4 -C 6 -cycloalkyl Wherein said ring is optionally substituted by hydroxy;n n n B is a bond, -O- or-(CHR) m ;n n n n is 1 or 2;n n n m is 1, 2 or 3;n n n Excludes compounds in which A and B are simultaneously bonded and Y is -CHR-. |