| abstract |
The present invention relates to a composition for treating anti-arthritis genes comprising an anti-angiogenesis gene or fragments thereof, and more particularly, angiostatin, endostatin, and platelet factor-4. 4) having angiogenic inhibitory activity, including thrombospondin-1 (TSP-1), thrombospondin-2, METH-1, METH-2 and hepatocyte growth factor Gene therapy for the treatment of rheumatoid arthritis by preparing a recombinant vector expressing a gene encoding a protein or a fragment thereof, and transplanting the recombinant vector or cell line transfected or transduced with the recombinant vector to the lesion of arthritis patient and the Provided are compositions for gene therapy. The gene therapy composition of the present invention is useful for the treatment of arthritis in which no effective treatment has been developed to date by inhibiting the growth and subsequent inflammation of synovial cells at the site of onset by continuously providing antiangiogenic factors to the knees of arthritis patients. Can be used. |