| abstract |
The salts of the compounds of formula I * or at least one salt forming group, if present, are described.n n n <Formula I *>n n n n n n n n Wheren n n R 1 is lower alkoxycarbonyl,n n n R 2 is sec- or tert-lower alkyl or lower alkylthio-lower alkyl,n n n R 3 is phenyl unsubstituted or substituted by one or more lower alkoxy groups, or C 4 -C 8 cycloalkyl,n n n R 4 is substituted or unsubstituted by lower alkyl or phenyl-lower alkyl and has from 1 to 4 heteroatoms selected from nitrogen, oxygen, sulfur, sulfinyl (-SO-) and sulfonyl (-SO 2- ). Phenyl or cyclohexyl, each substituted at the 4-position by unsaturated heterocyclyl bonded via a ring carbon atom, having from 5 to 8 ring atoms,n n n R 5 is one of the groups described for R 2 independently of R 2, n n n R 6 is lower alkoxycarbonyl independently of R 1 .n n n These compounds are inhibitors of retroviral aspartate protease and can be used, for example, in the treatment of AIDS. They exhibit good pharmacokinetic properties. |