| abstract |
The present invention relates to compounds of the general formula (I), N-oxides, pharmaceutically acceptable addition salts and stereochemical isomers thereof, and methods for their preparation, compositions containing them, and their use as medicaments.n n n n n n n n Wheren n n n is 0, 1 or 2;n n n m is 1 or 2 provided that when m is 2 n is 1;n n n = Q is = O or = NR 3 ;n n n X is a covalent bond or a divalent radical of the formula -O-, -S- or -NR 3- ;n n n R 1 is Ar 1 , or Ar 1 C 1-6 alkyl or di (Ar 1 ) C 1-6 alkyl, wherein each C 1-6 alkyl group is optionally substituted;n n n R 2 is Ar 2 , Ar 2 C 1-6 alkyl, Het or HetC 1-6 alkyl;n n n R 3 is hydrogen or C 1-6 alkyl;n n n L is a piperidine derivative of the general formula (a-1) or a spiro piperidine derivative of the general formula (a-2),n n n Ar 1 is phenyl or substituted phenyl;n n n Ar 2 is naphthalenyl; Phenyl; Or substituted phenyl;n n n Het is a monocyclic or bicyclic heterocycle, each of which may be optionally substituted on a carbon atom. |