| abstract |
Novel compounds of formula I, pharmaceutically acceptable salts of acidic compounds of formula I, and prodrugs thereof are cancers associated with overexpression of gelatinase-A and / or gelatinase-B, in particular skin cancer, breast cancer, prostate It can be used for the treatment or inhibition of cancer, colorectal cancer, lung cancer and gastric cancer and is also useful for other diseases associated with uncontrolled extracellular matrix degeneration, including rheumatoid arthritis, osteoarthritis, multiple sclerosis, corneal ulcers, periodontal disease, etc .:n n n [Formula I]n n n n n n n n [Wherein R 1 is hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, substituted alkoxy, aryloxy or alkylalkoxy, R 2 is aryloxy to be]. |