http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100466254-B1

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filingDate 2002-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2005-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2005-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-100466254-B1
titleOfInvention Conjugates Comprising Oligonucleotide And Hydrophilic Polymers for Gene Transfer, Hybrid Polyion Complex Micelles Self-assembled from Said Conjugates and Their Manufacturing Method
abstract The present invention is a gene delivery conjugate that can be used for the treatment of refractory diseases,n n n An oligonucleotide to be delivered into a cell, a gene delivery conjugate comprising a hydrophilic polymer and a terminal group of the oligonucleotide covalently linked to a hydrophilic polymer,n n n Disclosed is a polymer electrolyte composite micelle formed by ionic interaction between the gene delivery conjugate and a cationic peptide or cationic polymer.n n n According to the polymer electrolyte composite micelle according to the above configuration, the oligonucleotide can be efficiently delivered into the cell, and the antisense oligonucleotide can be exhibited at a relatively low concentration, which is very useful in basic research and medical field for biotechnology.
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