http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100463880-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B27D3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C02F11-123 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P41-00 |
| filingDate | 2003-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2005-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2005-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-100463880-B1 |
| titleOfInvention | The method of preparing optically active 2-hydroxy-4-phenylbutyronitrile and their esters by enzymatic method in non- solvent phase. |
| abstract | The present invention relates to the preparation of optically active 2-hydroxy-4-phenylbutyronitrile and ester derivatives thereof by enzymatic methods in a non-solvent, and more particularly to an organic solvent. After dissolving the racemic 2-hydroxy-4-phenylbutyronitrile in an acyl donor without using it, the lipase, a biocatalyst, is added by itself or immobilized to stereoselectively select one hydroxyl group. By esterification, optically active 2-hydroxy-4-phenylbutyronitrile and ester derivatives thereof are prepared.n n n In the present invention, unlike the conventional manufacturing method, since the reaction is performed without using an organic solvent, the process is easy and environmentally friendly, and the reaction is carried out by controlling the equilibrium state thermodynamically by maintaining the concentration of the reactor mass. It can be promoted and it is possible to repeat use of acyl donor and biocatalyst, so it is very economically excellent. It is also possible to prepare 2-hydroxy-4-phenylbutyronitrile and ester derivatives thereof having high yield and high optical purity. |
| priorityDate | 2003-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 72.