| abstract |
The present invention relates to antagonists against vanilloid receptors (VR) and pharmaceutical compositions containing them.n n n Diseases associated with the activity of vanilloid receptors include pain, acute pain, chronic pain, neuropathic pain, postoperative pain, migraine, arthralgia, neuropathy, nerve damage, diabetic neuropathy, neurodegenerative diseases, neurological skin disease, stroke, bladder hypersensitivity , Respiratory abnormalities such as irritable bowel syndrome, asthma and chronic obstructive pulmonary disease, skin, eye and mucous membrane irritation, fever, gastric-duodenal ulcer, inflammatory bowel disease and inflammatory diseases. The present invention provides pharmaceutical compositions for the prevention and treatment of these diseases. |