| abstract |
Compounds of formula (I) are inhibitors of rotamase enzymes, in particular FKBP-12 and FKBP-52.n n n <Formula I>n n n n n n n n Wheren n n A is unbranched C 3 -C 5 alkylene optionally substituted with C 1 -C 6 alkyl;n n n X is O, S, NH or N (C 1 -C 6 alkyl);n n n Y is O, S, NH or N (C 1 -C 6 alkyl);n n n R is a non-aromatic heterocyclic group of a C-linked 4- to 6-membered ring containing one nitrogen heteroatom; The group is optionally C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 3 -C 7 cycloalkyl, aryl, het, -CO 2 (C 1 -C 6 alkyl), -CO (het), Is substituted with 1, 2 or 3 substituent (s) each independently selected from -CONR 5 R 6 and -CO (aryl), said alkyl and alkenyl optionally being C 3 -C 7 cycloalkyl, aryl, het 1 or 2 substituent (s) each independently selected from -O (aryl), -O (C 1 -C 2 alkylene) aryl, -CO (het), -CONR 5 R 6 and -CO (aryl) Is replaced by.n n n The compound promotes the regeneration and proliferation of nerve cells and thus can be used to treat neurodegenerative diseases or neurological diseases resulting from other diseases involving nerve damage. |