http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100441348-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C50-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D223-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D223-20 |
| filingDate | 2001-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2004-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2004-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-100441348-B1 |
| titleOfInvention | A Method for the Preparation of 6-Morphanthridone, the Intermediate of Epinastine |
| abstract | The present invention relates to a novel process for preparing 6-morphantridone, which is an intermediate required for the production of epiastine hydrochloride (Epinastine HC1).n n n Epinastine is 9,13b-dihydro-1H-dibenz [c, f] imidazole [1,5-a] azin-3-amine (9,13b-dihydro-1H-drbenz [c, f] It is the abbreviation for imidazo [1,5-a] azepin-3-amine, and its hydrochloride treats or prevents pain, especially chronic or infection-induced pain, and especially migraines.n n n In the present invention, the anthraquinone of formula (II) is reacted with sodium azide to obtain morphanetridine-6,11-dione of formula (III) to obtain sodium borohydride ( Sodium borohydride) is mixed with trifluoroacetic acid used as a solvent and an activator to prepare 6-morphantridone of Structural Formula (I), which is an intermediate of epinastine hydrochloride. Excluding the use of strong phosgene, anthraquinone of formula (II), which is inexpensive and easy to purchase, can be used as a starting material. |
| priorityDate | 2001-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.