http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100424735-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-16 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C403-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C317-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C403-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C403-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-72 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-65 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C317-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C317-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C317-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C317-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C315-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C315-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C319-20 |
| filingDate | 2001-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2004-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2004-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-100424735-B1 |
| titleOfInvention | A Practical and Efficient Synthetic Method of Retinoic Acid and Its Derivatives |
| abstract | The present invention provides a C 15 allyl disulfone compound (Formula 1), an intermediate compound that can be used for the synthesis of retinol and carotene-based compounds, and a method for preparing the same, and a retinol-based polyene chain structure compound using the compound as an intermediate, in particular Provided is a method for preparing a retinoic acid (Formula 2) and an ester compound of a retinol acid (alkyl retinoate, Formula 3). It also provides an efficient method for the synthesis of tocopheryl retinoate, an ester compound of tocopherol and retinol acid. A method for preparing an allyl disulfone compound (Formula 1) uses a cyclo-geranyl sulfone compound as a starting material, and reacts it with a C 5 haloallylic sulfide compound to expand a thio-sulfone having a carbon chain. Obtain the compound. In the thio-sulfone compound, sulfide is selectively oxidized to sulfone to obtain C 15 allyl disulfone (Formula 1). When the compound of Formula 1 is reacted with C 5 halo-acid or C 5 halo-ester compound under excessive base conditions, the desulfonation reaction proceeds sequentially, respectively, the retinoic acid of Formula 2 and the formula The ester compound of retinol acid of 3 (alkyl retinoate) can be obtained efficiently. |
| priorityDate | 2000-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 91.