http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100417620-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-47 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D521-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 |
| filingDate | 1996-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2004-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2004-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-100417620-B1 |
| titleOfInvention | 2-quinolone derivatives having a farnesyl transferase inhibiting function |
| abstract | The present invention relates to compounds of formula (I) having a paranesyltransferase inhibitory activity, stereoisomeric forms thereof and pharmaceutically acceptable acid or base addition salts; A method for producing the same, a composition containing them, and a medicament containing them as medicines.n n n (I)n n n n n n n n Wherein the dashed line represents any bond; X is oxygen or sulfur; R 1 is hydrogen, C 1-12 alkyl, Ar 1, Ar 2 C 1-6 alkyl, quinolinyl C 1-6 alkyl, pyridyl C 1-6 alkyl, hydroxy C 1-6 alkyl, C 1- 6 alkyloxy C 1-6 alkyl, mono- or di (C 1-6 alkyl) amino C 1-6 alkyl, amino or C 1-6 alkyl, or formula -Alk 1 -C (= O) -R 9, -Alk 1 -S (O) -R 9 or -Alk 1 -S (O) 2 -R 9 ( wherein, Alk 1 is a C 1-6 alkanediyl, R 9 is hydroxy, C 1-6 alkyl , C 1-6 alkyloxy, amino, C 1-8 alkylamino, or a radical of C 1-6 alkyloxycarbonyl a C 1-8 alkylamino Im) substituted, R 2 and R 3 are each independently hydrogen, , hydroxy, halo, cyano, C 1-6 alkyl, C 1-6 alkyloxy, hydroxy C 1-6 alkyloxy, C 1-6 alkyloxy C 1-6 alkyloxy, amino C 1-6 alkyl (C 1-6 alkyl) aminoC 1-6 alkyloxy, Ar 1 , Ar 2 C 1-6 alkyl, Ar 2 oxy, Ar 2 C 1-6 alkyloxy, hydroxycarbonyl, C 1-6 alkyloxycarbonyl, trihalomethyl, trihalomethoxy, C 2-6 alkenyl, or R 2 and R 3 on adjacent positions may together form a divalent radical, R 4 and R 5 are each independently selected from the group consisting of hydrogen, Ar 1 , C 1-6 alkyl, C 1-6 alkyloxy C 1-6 alkyl, C 1-6 alkyloxy, C 1-6 alkylthio, amino, hydroxy-carbonyl, C 1-6 alkyloxycarbonyl, C 1-6 alkyl S (O) C 1- 6 alkyl, or C 1-6 alkyl S (O) 2 C 1-6 alkyl; R 6 and R 7 are each independently hydrogen, halo, cyano, C 1-6 alkyl, C 1-6 alkyloxy or Ar 2 oxy; R 8 is selected from the group consisting of hydrogen, C 1-6 alkyl, cyano, hydroxycarbonyl, C 1-6 alkyloxycarbonyl, C 1-6 alkyloxycarbonyl C 1-6 alkyl, cyanoC 1-6 alkyl, C 1-6 alkyl, C 1-6 alkylcarbonyl, C 1-6 alkylcarbonyl, hydroxyC 1-6 alkyl, aminoC 1-6 alkyl, mono- or di (C 1-6 alkyl) amino C 1-6 alkyl, haloC 1-6 alkyl, C 1-6 alkyloxyC 1-6 alkyl, aminocarbonylC 1-6 alkyl, Ar 1 , Ar 2 C 1-6 alkyloxyC 1-6 alkyl , C 1-6 alkylthioC 1-6 alkyl; R 10 is hydrogen, C 1-6 alkyl, C 1-6 alkyloxy or halo; R 11 is hydrogen or C 1-6 alkyl. |
| priorityDate | 1995-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 276.