http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100402561-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C281-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C281-00 |
| filingDate | 1999-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2003-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2003-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-100402561-B1 |
| titleOfInvention | Hydrazine derivatives |
| abstract | The present invention provides hydrazine derivatives of formula (I) and pharmaceutically acceptable salts thereof that inhibit the release of tumor necrosis factor alpha (TNF-α) from cells:n n n Formula In n n n n n n n Wheren n n R 1 is lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl, aryl or aryl-lower alkyl;n n n R 2 is an acyl group derived from an α-, β-, γ- or δ- (amino, hydroxy or thiol) carboxylic acid, wherein the amino, hydroxy or thiol group is optionally lower alkylated or the amino group is optionally acylated , Sulfonylated or amidated and all functional groups present in the side chain are optionally protected) or a group of the formula Het (CH 2 ) m CO;n n n R 3 is hydrogen, lower alkyl, halo-lower alkyl, cyano-lower alkyl, amino-lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, lower alkoxycarbonyl-lower alkyl, lower cycloalkyl-lower alkyl Aryl-lower alkyl, heterocyclyl-lower alkyl, heterocyclylcarbonyl-lower alkyl, lower alkenyl, lower alkynyl, lower cycloalkyl, aryl-lower alkenyl, aryl or heterocyclyl;n n n R 4 is lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl, or a group of the formula X-aryl, X-heteroaryl or — (CH 2 ) n —CH═CR 5 R 6 ;n n n R 5 and R 6 together are lower alkylene in which one CH 2 group is optionally substituted with a heteroatom;n n n Het is heterocyclyl;n n n X is a spacer group;n n n m is 0, 1, 2, 3 or 4;n n n n is 1 or 2.n n n They can be used as medicaments especially in the treatment of inflammatory and autoimmune diseases, osteoarthritis, respiratory diseases, tumors, cachexia, cardiovascular disease, fever, bleeding and sepsis. |
| priorityDate | 1998-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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