http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100392692-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C261-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C01C3-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-02 |
| filingDate | 2001-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2003-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2003-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-100392692-B1 |
| titleOfInvention | A Method for the Preparation of Epinastine and a Pharmaceutically Acceptable Salt thereof |
| abstract | The present invention relates to a novel process for preparing epiastine and its pharmaceutically acceptable salts.n n n Epineast is a 9,13b-dihydro-1H-dibenz [c, f] imidazole [1,5-a] azin-3-amine (9,13b-dihydro-1H-dibenz [c, f] A short name for imidazole [1,5-a] azepine-3-amine), the hydrochloride treats or prevents pain, especially chronic or infection-induced pain, and especially migraines.n n n In the present invention, cyanogen bromide, bromine, and N-methyl-benzylamine are added to 6-aminomethyl-6,11-dihydro-5H-dibenz [b, e] azepine, which is a compound of formula (II). Instead of the reaction, cyanamide or potassium cyanate is reacted to produce epinastine, thereby preventing the generation of highly toxic hydrogen bromide gas, which is a problem of the prior art, and reacting in aqueous solution instead of conventional ethanol and organic solvent solutions to produce epinastine. As a result, the reaction was stabilized, the resulting solid phase was easily separated and the yield was increased by about 10%. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021025442-A1 |
| priorityDate | 2001-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.