| abstract |
A quinuclidine derivative of the formula (I), a salt thereof, an N-oxide thereof or a quaternary ammonium salt thereof, and a pharmaceutical composition containing the same.n n n Formula In n n n n n n n In the formula (I)n n n The ring A is a heteroaryl group or a 5- to 7-membered saturated heterocyclic group containing 1 to 4 hetero atoms selected from an aryl group, a cycloalkyl group, a cycloalkenyl group, an oxygen atom, a nitrogen atom and a sulfur atom, Lt; / RTI >n n n X is a single bond or a methylene group,n n n R is a group selected from the group consisting of halogen atom, hydroxyl group, lower alkoxy group, carboxyl group, lower alkoxycarbonyl group, lower acyl group, mercapto group, lower alkylthio group, sulfonyl group, , A lower alkane sulfonamide group, a carbamoyl group, a thiocarbamoyl group, a mono- or di-lower alkylcarbamoyl group, a nitro group, a cyano group, an amino group, a mono- or di- Or a lower alkyl group which may be substituted by a halogen atom, a hydroxyl group, a lower alkoxy group, an amino group or a mono- or di-lower alkylamino group,n n n l is 0 or 1,n n n m is 0 or an integer of 1 to 3,n n n n is an integer of 1 or 2;n n n The compounds have an antagonistic effect on muscarinic M 3 receptors and are useful as agents for the prevention and treatment of urinary, respiratory or digestive diseases. |