| abstract |
Aqueous pharmaceutical compositions that can be sprayed into the nasal cavity of a human, and methods of using the compositions, and preferably methods of making the compositions comprising using anti-inflammatory steroids such as triamcinolone acetonide, and non-aromatic forms of the composition :n n n (A) a pharmaceutically effective amount of solid particles for effectively treating a physical condition by being present on the mucosal surface of the nasal cavity; And (B) an effective amount of suspending agent to maintain the particles uniformly dispersed in the composition and to impart the following thixotropy to the composition: (i) a composition that is gel-form and relatively high in position viscosity in the unshear form ; (ii) because the composition is sheared when the composition is formulated for spraying, the viscosity of the composition is relatively low so that it readily enters through the nasal passages in dust form to deposit on the mucosal surface of the nasal cavity; And (iii) in the form deposited on the mucosal surface, the composition is resistant to removal from the mucosal surface by intrinsic mucus forces present in the nasal cavity because the viscosity of the composition is relatively high. |