abstract |
The present invention relates to compounds of formulan n n Formula 1n n n n n n n n Food,n n n R 1 is C 1-6 alkoxy, C 3-7 cycloalkoxy, C 3-7 cycloalkylmethoxy, benzyloxy or C 1-4 alkoxy wholly or partially fluorine substituted,n n n R 2 is C 1-4 alkyl,n n n R 3 is hydrogen or C 1-4 alkyl, orn n n Both R2 and R3 together with both carbon atoms to which they are attached form a hydrocarbon ring which is shielded via a 5-, 6- or 7-membered, if desired oxygen atom,n n n R4 is phenyl, pyridyl, R41, R42 and R43 substituted phenyl or R44, R45, R46 and R47 substituted pyridyl, whereinn n n R41 is hydroxy, halogen, cyano, carboxyl, trifluoromethyl, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkoxycarbonyl, C 1-4 alkylcarbonyl, C 1-4 alkylcarbonyloxy, amino, mono-or it is a -C 1-4 alkylamino or C 1-4 alkylcarbonylamino,n n n R42 is hydrogen, hydroxy, halogen, amino, trifluoromethyl, C 1-4 alkyl or C 1-4 alkoxy,n n n R43 is hydrogen, halogen, C 1-4 alkyl or C 1-4 alkoxy,n n n R44 is hydroxy, halogen, cyano, carboxy, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkoxy carbonyl or amino,n n n R45 is hydrogen, halogen, amino or C 1-4 alkyl,n n n R46 is hydrogen or halogen,n n n R 47 is hydrogen or halogen.n n n These compounds are effective new PDE-inhibitors. |