http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100380610-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D279-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-522 |
| filingDate | 1995-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2003-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2003-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-100380610-B1 |
| titleOfInvention | Compounds Useful as Antiproliferative and GARFT Inhibitors |
| abstract | The compounds represented by formula (I) and their pharmaceutically acceptable salts are good GARFT inhibitors and are in equilibrium with their 4-hydroxy tautomers and exist in the form of diastereomeric mixtures. A represents a sulfur atom, CH 2 or selenium; Z represents a substituted or unsubstituted C 1 to C 3 alkyl group, C 2 to C 3 alkenyl group, C 2 to C 3 alkynyl group or amino group, or a sulfur atom or an oxygen atom; X is a substituted or unsubstituted C 1 ~ C 6 alkyl group, a substituted or unsubstituted C 2 ~ C 6 alkenyl group, a substituted or unsubstituted C 2 ~ C 6 alkynyl group; -C (O) E wherein E is a hydrogen atom, a substituted or unsubstituted C 1 to C 3 alkyl group, a substituted or unsubstituted C 2 to C 3 alkenyl group, a substituted or unsubstituted C 2 to C 3 alkynyl group , Substituted or unsubstituted OC 1 to C 3 alkoxy group, or NR 10 R 11 wherein R 10 and R 11 each represent a hydrogen atom, a substituted or unsubstituted C 1 to C 3 alkyl group, a substituted or unsubstituted C 2 A C 3 alkenyl group and a substituted or unsubstituted C 2 -C 3 alkynyl group; The group NR 10 R 11 in R 10 and R 11 is exemplified above, respectively; Hydroxy; Nitro; SR 12 wherein R 12 is a hydrogen atom, a substituted or unsubstituted C 1 to C 6 alkyl group, a substituted or unsubstituted C 2 to C 6 alkenyl group, or a substituted or unsubstituted C 2 to C 6 alkynyl group; Cyano; Or C 1 -C 3 alkoxy; And R 1 and R 2 each independently represent a moiety that is bonded to a hydrogen atom or CO 2 to form a hydrolyzable ester group. These compounds and salts are useful as antiproliferative agents. The present invention is directed to pharmaceutical compositions and methods of applying these compounds as GARFT inhibitors or antiproliferative agents. The invention also relates to intermediate compounds useful in the preparation and synthesis of these compounds. |
| priorityDate | 1994-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 66.