http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100379300-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D309-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-16 |
| filingDate | 2000-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2003-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2003-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-100379300-B1 |
| titleOfInvention | Sequential catalytic asymmetric allyl transfer reactions for the enantioselective synthesis of new pyran derivatives |
| abstract | The present invention is made by reacting an allylorganosilicon compound of formula (III) with an aldehyde compound of formula (IV) in the presence of a (R)-or (S) -BINOL-Ti [OCH (CF 3 ) 2 ] complex An optically active hydroxysilane derivative of formula (II) is prepared, which is reacted with trimethylsilyl chloride to protect the hydroxy group, and reacted with an aldehyde derivative of formula (Va) or (Vb), followed by a Lewis acid such as TMSNTf 2 Process for preparing optically active 2,6-disubstituted 4-methylenetetrahydropyran derivatives of formula (I) characterized by treatment with a catalyst and novel optically active 2,6-disubstituted compounds of formula (I) thus prepared 4-methylenetetrahydropyran derivatives are provided. The present invention also provides novel optically active compounds of formula (II) and novel allyltransfer reagents of formula (III) and methods for their preparation.n n n or (I)n n n (II)n n n (III)n n n R 1 CHO (IV)n n n (Va) or (Vb)n n n In the above formula, R 1 is an alkyl group having 1 to 10 carbon atoms; (Ii) an alkenyl group or an allenyl group having 1 to 10 carbon atoms including one or more double bonds; (Iii) substituted or unsubstituted aliphatic compounds; (Iii) a group derived from the compound of formula (VI):n n n (Ⅵ)n n n (In formula VI, R is lower alkyl, lower alkoxy, substituted or unsubstituted phenyl group, n is selected from 0 or an integer from 2 to 10.); Or (iii) a primary alcohol in which a hydroxy group having 1 to 10 carbon atoms is protected (a protecting group is selected from benzyl group, trialkylsilyl group and tetrahydrofuran),n n n R 2 is (i) an alkyl group having 1 to 10 carbon atoms; (Ii) an alkoxy group having 1 to 10 carbon atoms; (Iii) a substituted or unsubstituted benzyl group,n n n R 3 represents H, or R 2 and R 3 together with the carbon atom to which they are attached In which n is 1 or 2, in which case the oxa (—O—) group is in antiposition with R 1 ; R 4 represents a lower alkyl group having 1 to 6 carbon atoms; R 5 represents a substituted or unsubstituted lower alkyl group having 1 to 6 carbon atoms or a substituted or unsubstituted aryl group; X and Y each independently represent a halogen or alkoxy group.) |
| priorityDate | 2000-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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