| abstract |
The present invention relates to novel compounds useful as thrombin inhibitors. More specifically, the present invention provides a novel sulfonyl derivative represented by the following Chemical Formula 1, which exhibits potent thrombogenic inhibitory effect by selectively inhibiting tropine, a method for preparing the same, and preventing blood coagulation or treating various thrombosis containing the compound as an active ingredient. The pharmaceutical composition for:n n n [Formula 1]n n n n n n n n In the above formula,n n n R 1 represents hydroxyl, alkyloxy, amino or alkylamino,n n n R 2 and R 3 each independently represent lower alkyl or cycloalkyl,n n n R 4 represents hydrogen, lower alkyl or amino,n n n n is an integer of 1-5. |