| abstract |
Compounds of formula (I), or pharmaceutically or veterinary acceptable salts thereof, or pharmaceutically or veterinary acceptable solvates thereof are MMP inhibitors that are particularly useful for tissue ulcer formation, wound healing and treatment of skin diseases.n n n <Formula I>n n n n n n n n Wheren n n Dotted lines indicate occasional bonding,n n n A is C or CH,n n n B is CH 2 , O or not present, provided that when A is C, B is not O,n n n R 1 and R 2 are independently hydrogen, in some cases, C 1 -C 4 alkoxy or C 1 -C 6 alkyl substituted by phenyl, or C 1 -C 6 alkenyl know each other,n n n Together with the carbon atoms to which they are attached, optionally form a heteroatom linking group selected from O, SO, SO 2 and NR 6 or optionally a benzo fused C 3 -C 5 cycloalkyl group,n n n R 3 is hydrogen, halo, R 7 or OR 7 ,n n n R 4 is hydrogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, trifluoromethyl or halo,n n n R 6 is hydrogen or C 1 -C 4 alkyl,n n n R 7 is phenyl, thienyl, furyl, pyridinyl, pyrimidinyl, naphthyl, indanyl, benzothienyl, benzofuranyl, 2,3-dihydrobenzofuranyl, indolyl, quinolinyl, isoqui Monocyclic or bicyclic ring systems selected from nolinyl, benzodioxolyl, benzimidazolyl, benzoxazolyl, benzothiazolyl and benzodioxanyl, and these ring systems are optionally C 1 -C 4 alkoxy or the hydroxy C 1 -C 4 alkyl, as the case may be C 1 -C 4 a C 1 -C alkoxy or hydroxy-4 alkoxy, C 1 -C 4 alkylthio, trifluoromethyl, trifluoromethoxy substituted with Optionally substituted with one or two substituents selected from oxy, halo and cyano,n n n m is 1 or 2,n n n n is 0, 1 or 2. |