| abstract |
The present invention relates to novel compounds useful as thrombin inhibitors. More specifically, the present invention is a novel heterocyclic alanine derivative represented by the following Chemical Formula 1 having a powerful effect in inhibiting thrombogenesis, a method for preparing the same, and a medicament for preventing blood coagulation or treating various thrombosis containing the compound as an active ingredient. Regarding the composition:n n n [Formula 1]n n n n n n n n In the above formula,n n n X and Y each independently represent O, S, NH, N or CH,n n n R 1 represents substituted or unsubstituted aryl,n n n R 2 and R 3 each independently represent lower alkyl or cycloalkyl,n n n R 4 represents hydrogen, lower alkyl or amino. |