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filingDate 2002-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2002-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9738254d4f41d90817c8ac2f391e94a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db31c258c1cc49b6e2028616780f8900
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5c6ff3f27589355c159547bdc8f5423
publicationDate 2002-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-100360139-B1
titleOfInvention Cyclopropane derivatives and method of preparing the same
abstract Compounds of formula 12 are known to have potent antiviral activity (JP-A- 5/78357).n n n Formula 12n n n n n n n n However, the method described in the above publication is a time-consuming process involving the protection and deprotection of intermediates and is not suitable for industrial scale production. The inventors have found, however, that the cyclopropane derivatives of formula 3 are useful for preparing the compounds of formula 12 shown above simply and conveniently in high yield.n n n Formula 3n n n n n n n n In the above formula,n n n B is a purine derivative residue.n n n Accordingly, the present invention provides the following novel starting materials (3-oxa-2-oxobi), which are useful for the preparation of cyclopropane derivatives of Formula 3, which are useful for preparing compounds of Formula 12, which are antiviral agents, simply and conveniently in high yield. Cyclo [3.1.0] hexane-1-yl] methanol and process for preparing cyclopropane derivative of formula (3) and also (3-oxa-2-oxobicyclo [3.1.0] hexane-1-yl] methanol Useful intermediates were found.n n n Formula 1
priorityDate 1994-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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