| abstract |
The present invention provides a compound of formula (I)n n n <Formula I>n n n n n n n n Wheren n n R is phenyl, C 3 -C 7 cycloalkyl or heteroaryl, each of which may optionally be benzo- or C 3 -C 7 cycloalkyl-fused, respectively, and the benzo- or C 3 -C 7 cycloalkyl-fused portion Optionally containing C 1 -C 4 alkyl, fluoro (C 1 -C 4 ) alkyl, C 1 -C 4 alkoxy, fluoro (C 1 -C 4 ) alkoxy, phenoxy, C 2 -C 4 alka Noyl, halo, C 1 -C 4 alkoxycarbonyl, C 3 -C 7 cycloalkyl,-(S) O m (C 1 -C 4 alkyl), cyano, -NR 2 R 3 , -S (O) m NR 2 R 3 , -NR 4 (C 1 -C 4 alkanoyl) and -CONR 2 R 3 may be substituted with 1 to 3 substituents independently selected from R, or R is 2,3-dihydrobenzo [ b] furanyl or chromanyl;n n n R 1 is H or C 1 -C 6 alkyl;n n n W is a direct bond, methylene or ethylene;n n n X is unbranched C 2 -C 4 alkylene;n n n Y is phenyl, naphthyl, benzyl, pyridyl, thienyl or C 3 -C 7 cycloalkyl, each of which is C 1 -C 4 alkyl, fluoro (C 1 -C 4 ) alkyl, C 1 -C 4 alkoxy Optionally substituted with 1 to 3 substituents independently selected from the group consisting of fluoro (C 1 -C 4 ) alkoxy, halo and cyano;n n n Ar is phenyl, naphthyl, benzyl, thienyl, benzo [b] thienyl or indolyl, each of which is C 1 -C 4 alkyl, fluoro (C 1 -C 4 ) alkyl, C 1 -C 4 alkoxy, Or optionally substituted with 1 to 3 substituents independently selected from the group consisting of fluoro (C 1 -C 4 ) alkoxy, halo and cyano, or Ar is 1,3-benzodioxolan-4 or 5-yl Or 1,4-benzodioxane-5 or 6-yl;n n n Z A is a pharmaceutically acceptable anion;n n n Provided that when W is a direct bond and R is optionally fused and optionally substituted heteroaryl, said heteroaryl is bonded to a carbonyl group by a ring carbon atom.n n n The compound is a tachykinin antagonist. |