http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100333749-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H17-02 |
| filingDate | 1994-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2002-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2002-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-100333749-B1 |
| titleOfInvention | O6-substituted guanine derivatives, their preparation and their use in tumor cell therapy |
| abstract | The formula (I) and the O 6 -heterylalkyl- or naphthylalkylguanine derivativen n n n n n n n Wherein X is O or S, R " and R "'are alkyl or substituted derivatives thereof, and R ' is H Or alkylhydroxyalkyl, R is (i) a cyclic group having at least one 5- or 6-membered heterocyclic ring or a substituted derivative thereof, optionally fused to it by a carbon ring or heterocyclic ring , Each heterocyclic ring has at least one heteroatom selected from O, N or S, or R is (ii) naphthyl or a substituted derivative thereof, and pharmaceutically acceptable salts thereof are O 6 - And exhibit the ability to reduce alkylguanine-DNA alkyltransferase (ATase) activity. A method for preparing this compound is also described. This compound is used in combination with an alkylating agent in a chemotherapeutic agent for tumor cells. |
| priorityDate | 1993-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 110.