http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100330135-B1
Outgoing Links
Predicate | Object |
---|---|
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 |
filingDate | 1998-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2002-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2002-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | KR-100330135-B1 |
titleOfInvention | Gene delivery process using nonviral gene delivery system targetting liver cancer |
abstract | The present invention relates to a gene delivery method and gene delivery method for delivering genes by targeting a liver cancer cell line by using an ASOR (asialoorosomucoid) that binds to ASGPr (asialoglycoprotein receptor) specifically present in liver cancer cells.n n n The present invention is to conjugate polylysine (PL) to an ASOR (asialoorosomucoid) that binds to ASGPr (asialoglycoprotein receptor) known to be specifically present in hepatocytes to prepare an ASOR-PL conjugate, and to prepare plasmids pSV2CAT, pCMV β-gal, pCMV-p53 was combined to obtain ASOR-PL-pSV2CAT plasmid complex, ASOR-PL-pCMV β-gal plasmid complex, and ASOR-PL-pCMV-p53 plasmid complex, which were then transferred to various liver cancer cell lines to transfer genes. By treating the oxyethylene-polyoxypropylene block copolymer to enhance the intracellular delivery efficiency of the gene 200%, there is an excellent effect of efficiently delivering the gene into liver cancer cells. |
priorityDate | 1998-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 232.